Severe overdosage could bring about coma, areflexia, cardiorespiratory depression and apnea. The consequences of overdosage is usually managed with benzodiazepine antagonist flumazenil.
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This isn't a complete listing of attainable Unintended effects. In the event you discover other effects not shown earlier mentioned, Call the health care provider or pharmacist.
Midazolam is usually used for the acute management of prolonged seizures. Extensive-time period use for that management of epilepsy isn't suggested as a consequence of the significant threat of tolerance (which renders midazolam and various benzodiazepines ineffective) and the numerous side effect of sedation.[16] A advantage of midazolam is the fact that in children it can be provided inside the cheek or in the nose for acute seizures, together with status epilepticus.
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Chances are you'll really feel drowsy for twenty-four to forty eight hours once the injection. Steer clear of driving or hazardous activity until finally the results of midazolam have worn off fully. Dizziness or drowsiness might cause falls, mishaps, or critical accidents.
It's not at all for household or extended-phrase use.Midazolam belongs to a class of medicines referred to as benzodiazepines, which make a calming impact on the brain and nerves (central anxious procedure). It is assumed to work by rising the result of a specific natural chemical (GABA) during the Mind.
Prolonged-expression usage of benzodiazepines is affiliated with lengthy-lasting deficits in memory, and display only partial recovery 6 months right after stopping benzodiazepines.[11] It truly is unclear no matter whether whole Restoration occurs right after more time intervals of abstinence. Benzodiazepines can cause or worsen depression.[eleven] Paradoxical enjoyment once in a while happens with benzodiazepines, like a worsening of seizures. Young children and elderly individuals or those having a history of abnormal Liquor use and persons that has a historical past of intense conduct or anger are at elevated hazard of paradoxical results.[eleven] Paradoxical reactions are notably connected with intravenous administration.
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Don't consume Alcoholic beverages Soon soon after having midazolam. midazolam can improve the consequences of alcohol, which could possibly be dangerous.
Drowsiness or dizziness may perhaps last lengthier in more mature Grownups. Use warning to stop falling or accidental harm.
Disadvantages include things like a large degree of breakthrough seizures—a result of the brief 50 %-life of midazolam—in above fifty% of folks taken care of, along with procedure failure in 14–eighteen% of individuals with refractory status epilepticus. Tolerance develops rapidly to the anticonvulsant outcome, and also the dose might must be greater by quite a few occasions to keep up anticonvulsant therapeutic consequences.
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